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BioResolve

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BioResolve

BioResolve columns from Waters are HPLC and UHPLC columns for the analysis of biomolecules and in particular mAb-based and related biotherapeutics. Three different modifications are available for different applications:

BioResolve RP mAb Polyphenyl: Polyphenyl modification for reversed-phase chromatography; material based on fused-core technology; for the analysis of intact and IdeS-digested mAbs
BioResolve SCX mAb: cation exchange modification; material is non-porous polymer according to L34; for the analysis of antibody charge variants
BioResolve SEC mAb : size exclusion modification; fully porous hybrid material; for the analysis of mAb aggregates (HMWS), monomers and fragments (LMWS)

Product Line

Products

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BioResolve Premier SCX mAb Column, 3 µm, 2.1 mm x 20 mm, 1/pk

186011020

€885.00

Product Type: HPLC Column Length: 20 mm Internal Diameter: 2.1 mm Particle Size: 3 µm Chemistry: Strong cation-exchange USP Class: L34 Manufacturer: Waters Delivery Time: approx. 5 days (product only available in Germany) Column Type: Analytical Column Endcapping: endcapped Mode of Separation: Ion Exchange Chromatography Hardware Type: Ready-to-use Column Matrix: Polymer Particle Morphology: spherical, non-porous pH Minimum: 2.0 pH Maximum: 7.0 Technology: HPLC

BioResolve Premier RP mAb Polyphenyl Column, 450 Å, 2.7 µm, 2.1 mm x 20 mm, 1/pk

186011019

€915.00

Product Type: HPLC Column Length: 20 mm Internal Diameter: 2.1 mm Particle Size: 2.7 µm Pore Size: 450 Å Chemistry: Phenyl USP Class: L11 Manufacturer: Waters Delivery Time: approx. 5 days (product only available in Germany) Column Type: Analytical Column Endcapping: endcapped Mode of Separation: Reversed Phase Chromatography (RP) Hardware Type: Ready-to-use Column Matrix: Silica Particle Morphology: spherical, solid core, porous shell pH Minimum: 2.0 pH Maximum: 7.0 Technology: HPLC

BioResolve SCX mAb Column, 3 µm, 4.6 mm x 100 mm, 1/pk with with eConnect Column Tag

186009060RF

€1,650.00

Product Type: HPLC Column Length: 100 mm Internal Diameter: 4.6 mm Particle Size: 3 µm Chemistry: Strong cation-exchange USP Class: L34 Manufacturer: Waters Delivery Time: approx. 5 days (product only available in Germany) Column Type: Analytical Column Mode of Separation: Ion Exchange Chromatography Hardware Type: Ready-to-use Column Matrix: Polymer Particle Morphology: spherical, non-porous pH Minimum: 3.0 pH Maximum: 11.0 Pressure Stability: 689 bar Technology: HPLC

BioResolve SCX mAb Column, 3 µm, 4.6 mm x 50 mm, 1/pk with eConnect Column Tag

186009058RF

€1,270.00

Product Type: HPLC Column Length: 50 mm Internal Diameter: 4.6 mm Particle Size: 3 µm Chemistry: Strong cation-exchange USP Class: L34 Manufacturer: Waters Delivery Time: approx. 5 days (product only available in Germany) Column Type: Analytical Column Mode of Separation: Ion Exchange Chromatography Hardware Type: Ready-to-use Column Matrix: Polymer Particle Morphology: spherical, non-porous pH Minimum: 3.0 pH Maximum: 11.0 Pressure Stability: 689 bar Technology: HPLC

BioResolve RP mAb Polyphenyl Column, 450Å, 2.7 µm, 4.6 mm X 150 mm, 1/pk with eConnect Column Tag

186008955RF

€1,310.00

Product Type: HPLC Column Length: 150 mm Internal Diameter: 4.6 mm Particle Size: 2.7 µm Pore Size: 450 Å Chemistry: Phenyl USP Class: L11 Manufacturer: Waters Delivery Time: approx. 5 days (product only available in Germany) Column Type: Analytical Column Mode of Separation: Reversed Phase Chromatography (RP) Hardware Type: Ready-to-use Column Matrix: Silica Particle Morphology: spherical, solid core, porous shell pH Minimum: 2.0 pH Maximum: 7.0 Pressure Stability: 689 bar Technology: U(H)PLC Temperature Minimum [°C]: 50 Temperature Maximum [°C]: 90

BioResolve RP mAb Polyphenyl Column, 450Å, 2.7 µm, 4.6 mm X 100 mm, 1/pk with eConnect Column Tag

186008954RF

€1,190.00

Product Type: HPLC Column Length: 100 mm Internal Diameter: 4.6 mm Particle Size: 2.7 µm Pore Size: 450 Å Chemistry: Phenyl USP Class: L11 Manufacturer: Waters Delivery Time: approx. 5 days (product only available in Germany) Column Type: Analytical Column Mode of Separation: Reversed Phase Chromatography (RP) Hardware Type: Ready-to-use Column Matrix: Silica Particle Morphology: spherical, solid core, porous shell pH Minimum: 2.0 pH Maximum: 7.0 Pressure Stability: 689 bar Technology: U(H)PLC Temperature Minimum [°C]: 50 Temperature Maximum [°C]: 90

BioResolve RP mAb Polyphenyl 450Å 2.7µm 4.6x50mm, 1/pk with eConnect Column Tag

186008953RF

€1,150.00

Product Type: HPLC Column Length: 50 mm Internal Diameter: 4.6 mm Particle Size: 2.7 µm Pore Size: 450 Å Chemistry: Phenyl USP Class: L11 Manufacturer: Waters Delivery Time: approx. 5 days (product only available in Germany) Column Type: Analytical Column Mode of Separation: Reversed Phase Chromatography (RP) Hardware Type: Ready-to-use Column Matrix: Silica Particle Morphology: spherical, solid core, porous shell pH Minimum: 2.0 pH Maximum: 7.0 Pressure Stability: 689 bar Technology: U(H)PLC Temperature Minimum [°C]: 50 Temperature Maximum [°C]: 90

BioResolve SEC mAb Guard, 200Å, 2.5 µm, 4.6 x 30 mm, 1/pk;

186009443

€530.00

Product Type: SEC/GPC Guard Columns Length: 30 mm Internal Diameter: 4.6 mm Particle Size: 2.5 µm Pore Size: 200 Å Chemistry: Diol USP Class: L33 Manufacturer: Waters Delivery Time: approx. 5 days (product only available in Germany) Endcapping: non endcapped Carbon Load: 12.0 % Bet Surface Area [m2/g]: 220.0 Mode of Separation: SEC / Aqueous Size Exclusion Chromatography (GFC) Hardware Type: Ready-to-use Column Matrix: Hybrid Particle Morphology: spherical, fully porous pH Minimum: 1.0 pH Maximum: 8.0 Technology: HPLC

BioResolve SEC mAb Column, 200Å, 2.5 µm, 7.8 x 300 mm, 1/pk;

186009441

€3,750.00

Product Type: SEC/GPC Columns Length: 300 mm Internal Diameter: 7.8 mm Particle Size: 2.5 µm Pore Size: 200 Å Chemistry: Diol USP Class: L33 Manufacturer: Waters Delivery Time: approx. 5 days (product only available in Germany) Column Type: Analytical Column Endcapping: non endcapped Carbon Load: 12.0 % Bet Surface Area [m2/g]: 220.0 Mode of Separation: SEC / Aqueous Size Exclusion Chromatography (GFC) Hardware Type: Ready-to-use Column Matrix: Hybrid Particle Morphology: spherical, fully porous pH Minimum: 1.0 pH Maximum: 8.0 Technology: U(H)PLC

BioResolve SEC mAb Column, 200Å, 2.5 µm, 7.8 x 150 mm, 1/pk;

186009439

€2,570.00

Product Type: SEC/GPC Columns Length: 150 mm Internal Diameter: 7.8 mm Particle Size: 2.5 µm Pore Size: 200 Å Chemistry: Diol USP Class: L33 Manufacturer: Waters Delivery Time: approx. 5 days (product only available in Germany) Column Type: Analytical Column Endcapping: non endcapped Carbon Load: 12.0 % Bet Surface Area [m2/g]: 220.0 Mode of Separation: SEC / Aqueous Size Exclusion Chromatography (GFC) Hardware Type: Ready-to-use Column Matrix: Hybrid Particle Morphology: spherical, fully porous pH Minimum: 1.0 pH Maximum: 8.0 Technology: U(H)PLC

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Technical Data

Phase	Modification	Particle size	Pore size	Surface area	C-content	Endcapped	USP	pH range
BioResolve mAb Polyphenyl	Phenyl	2.7 µm	450 Å	N/A	N/A	+	L11	1.0-8.0
BioResolve SCX mAb	N/A	3 µm	non-porous	N/A	N/A	+	L34	2.0-7.0
BioResolve SEC mAb	Diol	2.5 µm	200 Å	220 m²/g	12 %C	-	L20, L33, L59	2.5-8.0

Downloads

Brochures

HPLC SEC Sample Preparation
Waters Catalog 23-24 Biomolecule HPLC SEC SPE Brochure
SEC Standards
Waters Catalog 23-24 SEC Columns Standards SEC Brochure

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