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The RPSep columns are made of polystyrene divinylbenzene (PS/DVB). This makes these columns stable in a pH range from 0 to 14. They are also temperature stable and show a very tight particle size range of ± 0.5 μm for high efficiency. Some of these phases are alkylated by a patented technology.
| Phase | Modification | Particle size | pH range |
| PRX-1 | PS/DVB | N/A | 0-14 |
| ACT-1 C18 | PS/DVB, C18 | N/A | 2.0-14 |
| Poly-RP | PS/DVB | 4 μm | N/A |
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