Kromasil 100-10-diC4 4.6 x 300 mm

The Kromasil 100 diC4 HPLC column 300x4.6mm, 10µm, has a difunctional butyl modification on 100 Å silica. Due to the special bonding chemistry Kromasil 100 diC4 offers a robust C4-like selectivity with increased stability and controlled hydrophobic interaction. The phase is used in reversed-phase chromatography and is particularly interesting for biomolecular and preparative issues. Typical applications are peptides, GLP-1-related classes of actives, hydrophobic biomolecules, method development, purification and scale-up from analytical to larger HPLC scales.

Performance Characteristics and Benefits

• Spherical, fully porous silica with high mechanical stability
• High surface area and high pore volume for efficient separations and good loading capacity
• Narrow particle size distribution for high efficiency and reproducible results
• Broad phase spectrum for reverse-phase, normal-phase, HILIC, and SFC
• Suitable for analytical method development, routine analysis, scale-up, and preparative applications

Additional Information

The Kromasil series is based on highly stable, spherical, and fully porous silica particles. The silica matrix combines a high surface area, high pore volume, and a controlled pore structure with a narrow particle size distribution. This supports efficient packing beds, low pressure drops relative to performance, and good column and batch reproducibility. The Kromasil platform offers different pore sizes: 60 Å for small organic molecules, 100 Å for small molecules and peptides, and 300 Å for proteins and larger biomolecules. Appropriate Kromasil pre-column cartridges can be used to protect the analytical packing bed from particles, sample matrix, and hard-to-elute components.

Legal Notices

Kromasil is a registered trademark of the manufacturer Nouryon, Bohus, Sweden.