ODP2 HP-4E, 4.6 x 250 mm, HPLC column

The Shodex ODP2 HP HPLC column 250x4.6mm, 5µm, contains a macroporous polyhydroxymethacrylate gel without bonded alkyl groups. The optimised polymer surface produces a reversed-phase selectivity with stronger retention of highly polar compounds than many classical C18 materials while simultaneously allowing the use of alkaline eluents. Shodex ODP2 HP is characterised by high efficiency, low protein adsorption and a selectivity suitable for small drug substances, metabolites and LC‑MS analyses in protein‑rich matrices.

Features and Benefits

• Highly efficient polymer reverse-phase column
• Strong retention of polar compounds
• Resistant to alkaline eluents
• Low protein adsorption
• Suitable for LC-MS matrix samples

Additional Notes

ODP2 HP is based on fine-pored polyhydroxymethacrylate. Reverse-phase retention results from the controlled polymer backbone and not from an alkyl phase bound to silica. The polar surface and small pores limit the access of larger proteins to the interior of the packing, while small organic analytes are efficiently separated. The silica-free matrix also allows for operating conditions that may be critical for conventional silica columns.

Legal Information

ODP is a registered trademark of Resonac Corporation, Tokyo, Japan. ODP2 HP is a product line within the Shodex portfolio.