ACE Excel 3 C18-HL, 250 x 4.0mm, UoM: 1 * 1 items

The Avantor ACE Excel C18-HL HPLC/UHPLC column 250x4.0mm, 3µm, is based on an octadecylsilyl modification (other designations: ODS, RP-18, C18) with a higher ligand density and greater carbon loading than the traditional C18 phase. The Avantor ACE Excel C18-HL therefore exhibits stronger hydrophobic retention and an increased loading capacity for reversed-phase chromatography. It is particularly useful when handling analyte-rich samples, preparative approaches or methods with higher sample loads. The Excel format supports high efficiency and fast analyses on UHPLC and HPLC systems. Typical applications include process development, preparative separations, biogenic amines, amino acids, pharmaceutical intermediates and methods where stronger C18 retention is desired.

Features and Benefits

• UHPLC/HPLC hardware for high pressure stability and low system dispersion
• Ultra-inert, base-deactivated, fully porous silica particles
• Wide range of phases for rapid method development
• Excellent peak shape and reproducibility for acidic, basic, and neutral analytes
• Particle sizes for high resolution and fast routine analyses

Additional Information

Avantor ACE Excel combines ACE silica chemistry with a UHPLC-compatible column format. The high-purity, base-deactivated silica matrix minimizes secondary interactions and ensures reproducible retention times. The combination of inert silica, controlled ligand bonding, and pressure-stable hardware allows methods to be implemented in both UHPLC and conventional HPLC systems. Compatible Avantor ACE Excel guard cartridges protect the analytical column from the sample matrix and help maintain the performance of the Excel method over extended runs.

Legal Notices

Avantor ACE is a registered trademark of the manufacturer Avantor, Inc., Radnor, USA.