Carbo Sep USP L-19 CA-Form, SS 250 mm x 4.0 mm

The CarboSep USP L19 HPLC column (250 × 4.0 mm, 8 µm) is a Ca²⁺-based polymer phase with 8 % cross-linking, designed for methods requiring USP L19-like selectivity. CarboSep USP L19 is used for the HPLC separation of sugars and sugar alcohols when regulatory or methodological requirements specify this type of column. Applications include pharmaceutical quality control, food analysis and raw material testing.

Features and Benefits

• Polymer-based ligand-exchange resins for carbohydrates
• Various counterions, such as Na+, Ca2+, Pb2+, and K+, for targeted selectivity
• Cross-linking degrees of 4, 6, 7, and 8% to adjust porosity, resolution, and robustness
• Suitable for monosaccharides, disaccharides, and oligosaccharides

Additional Notes

The CarboSep series uses polymer-based packing materials with defined counterions and degrees of cross-linking. Unlike conventional silica phases, retention is not based on hydrophobic surface interactions, but rather on ligand exchange and size- or structure-dependent interactions between the carbohydrates and the polymer resin. This allows sugars, sugar alcohols, and oligosaccharides to be separated in highly aqueous eluents. The polymer backbone used is designed for routine applications in carbohydrate analysis; compatible CarboSep pre-column cartridges help keep matrix components out of the main column.

Legal Notices

CarboSep is a registered trademark of the manufacturer Concise Separations, San Jose, USA.