Dcpak PBT 5µm 10x4.0mm SFC Guard Columns

The DCpak PBT Pre-filter cartridges 10x4.0mm, 5µm, are used to protect DCpak PBT HPLC and SFC columns are used. They are suitable for methods in which matrix components, particles or strongly adsorbing co-eluting substances could interfere with the polymeric stationary phase. The 00011 is used as the pre-column holder.

Features and Benefits

• Polymeric achiral selectors for complementary HPLC and SFC selectivity
• No traditional amylose or cellulose phases; instead, robust polymer surfaces
• Suitable for structural isomers, positional isomers, hydrophilic substances, and peptides
• PBT, P4VP, PTZ, and PMPC cover different interaction profiles
• Use in normal-phase, reverse-phase, HILIC, and SFC depending on the phase and method
• Useful for impurity profiling, purity analysis, and method orthogonality

Additional Notes

DCpak differs fundamentally from Chiralcel, Chiralpak, or CROWNPAK, as its phases are achiral and polymer-based. The focus is on orthogonal separation mechanisms for structurally similar, polar, or difficult-to-separate achiral mixtures. The backbone is not derived from amylose or cellulose. Instead, polymeric selectors with defined chemical functionality are used, such as ester-, pyridine-, tetrazole-, or phosphorylcholine-based structures. The advantage of polymeric DCpak phases lies in their robustness and alternative selectivity compared to classical silica, C18, or HILIC phases. The disadvantage is that enantiomer separation, as seen with chiral polysaccharide phases, is not to be expected; DCpak should be used specifically for achiral selectivity challenges.

Legal Notices

DCpak is a registered trademark of Daicel Corporation, Osaka, Japan.