HALO 120 Å ELV C8, 5.0µm, 4.6x250mm

The HALO Elevate C8 HPLC column 250x4.6mm, 5µm, is based on an octysilyl phase (also known as OS, RP-8, C8) on a core-shell particle. In addition, the core-shell particle is modified with organosilane compounds to achieve high pH stability from 2 to 12 at temperatures up to 60°C. Thanks to the column’s high pH compatibility, bases can be separated from one another in their neutral state. This offers the advantage that the bases elute later and with better peak shape. The improved peak shape also allows for a higher loading capacity of the HALO Elevate C8, which can be very helpful in the analysis of impurities. Compared to the HALO Elevate C18, the HALO Elevate C8 exhibits comparable selectivity with shorter retention times. This allows methods to be specifically accelerated. This phase is useful for all separations that benefit from a higher pH or when bases in general are to be analyzed. Typical applications include, for example, antidepressants, cocaine, or triazoles.

Features and Benefits

• Core-shell particles for fast methods
• High pH stability (2–12 at 60°C) due to organosilane modification
• UHPLC performance on HPLC systems
• High efficiency
• Low backpressure

Additional Information

The HALO Elevate series is based on a core-shell material. This means that the particles have a non-porous core and a porous shell. This allows for high efficiency while maintaining low backpressure. As a result, UHPLC performance is possible with a standard HPLC system. A special modification of the silica surface using organosilane compounds results in high pH stability ranging from 2 to 12 at 60°C. This wide pH range can be used to analyze basic compounds in their neutral, uncharged state, leading to better peak shapes and higher loading capacity for basic compounds. The service life can be extended by using appropriate precolumn cartridges.

Legal Notices

HALO is a registered trademark of the manufacturer Advanced Materials Technology, Inc., Wilmington, USA.