Checkout using your account
Checkout as a new customer
Creating an account has many benefits:
Questions, MSDS, CoA?
Do you have any questions? Give us a call or send us an email!


The BIOshell A400 Protein C4 HPLC-/UHPLC column 150x0.3mm, 3.4µm, features a C4 modification on 400Å fused-core particles. The BIOshell A400 Protein C4 is used for proteins and larger peptides where moderate hydrophobic retention is required. Applications of the BIOshell A400 Protein C4 include protein characterisation, peptide/protein mixtures, biopharmaceutical samples and LC–MS-compatible RP methods.
BIOshell columns use fused-core particles designed for biomolecules. Depending on the phase, larger pores are available for intact proteins and antibodies, medium-sized pores for peptides and oligonucleotides, and HILIC-like surfaces for glycans. The short diffusion path of the core-shell particles promotes narrow peaks, while the surface chemistry is optimized for typical bio-LC applications. As a result, BIOshell can be used for fast, sensitive, and MS-compatible bioanalytics.
BIOshell is a registered trademark of the manufacturer Merck KGaA, Darmstadt, Germany.
| Brand | BIOshell |
|---|---|
| Product Type | CoreShell Column |
| Length | 150 mm |
| Internal Diameter | 0.3 mm |
| Particle Size | 3.4 µm |
| Chemistry | C4 |
| Chemistry Producers Term | A400 Protein C4 |
| Pore Size | 400 Å |
| USP Class | L26 |
| Carbon Load | 0.4 % |
| Bet Surface Area [m2/g] | 15.0 |
| Endcapping | endcapped |
| Country of Origin | Germany |
| Column Type | Capillary Column |
| Hardware Material | Stainless Steel |
| Hardware Type | Ready-to-use Column |
| pH Minimum | 2.0 |
| pH Maximum | 9.0 |
| Temperature Maximum [°C] | 90 |
| Mode of Separation | Reversed Phase Chromatography (RP) |
| Technology | HPLC |
| Matrix | Silica |
| Particle Morphology | spherical, solid core, porous shell |
| Pressure Stability | 600 bar |