Inertsil SIL-100A 3µm, HPLC-Column 60x4.0mm HPLC Column

The Inertsil SIL-100A HPLC column 60x4.0mm, 3µm, is a pure silica phase with a pore size of 100 Å for normal-phase chromatography. The unmodified, high-purity silica serves as the active stationary phase and enables separations via polar interactions and adsorption to silanol groups. Inertsil SIL-100A is also a key silica backbone of the Inertsil 3 Series. Typical applications include polar compounds, positional isomers, lipids, natural products, preparative normal-phase methods, and methods requiring a defined silica activity.

Performance Characteristics and Benefits

• High-purity silica
• Controlled pore structure and reproducible surface
• High inertness due to reduced silanol and metal activity
• Excellent peak shapes for acidic, neutral, and basic analytes
• Reliable reproducibility for routine analysis

Additional Notes

The Inertsil series is based on a high-purity, spherical silica matrix whose pore structure, particle size distribution, and surface are carefully controlled during production. Low metal contamination and careful surface treatment reduce the activity of free silanol groups. This minimizes undesirable secondary interactions—particularly tailing and adsorption with basic or chelating analytes—and promotes stable retention times. This reproducible silica matrix forms the basis for the various Inertsil modifications and ensures reliable selectivities across the series. Appropriate Inertsil pre-column cartridges should be used to protect the analytical packing bed from particles and the sample matrix and to extend column lifespan.

Legal Notices

Inertsil is a registered trademark of the manufacturer GL Sciences Inc., Tokyo, Japan.