Inertsil AX 5µm Conventional guard column 4.6 x 50mm HPLC Guard Columns

The Inertsil AX pre-columns 50x4.6mm, 5µm, are used to protect Inertsil AX HPLC columns with an inner diameter of 4.6mm. The pre-columns contain a packing material compatible with the analytical column and protect the main column from particles, matrix components, and heavily retained impurities. They are suitable for routine and method development applications in HPLC and LC/MS when longer column life and stable chromatographic performance are desired. Since these are precolumns, no additional holder is required.

Performance Characteristics and Benefits

• High-purity silica
• Controlled pore structure and reproducible surface
• High inertness due to reduced silanol and metal activity
• Excellent peak shapes for acidic, neutral, and basic analytes
• Reliable reproducibility for routine analysis

Additional Notes

The Inertsil series is based on a high-purity, spherical silica matrix whose pore structure, particle size distribution, and surface are carefully controlled during production. Low metal contamination and careful surface treatment reduce the activity of free silanol groups. This minimizes undesirable secondary interactions—particularly tailing and adsorption with basic or chelating analytes—and promotes stable retention times. This reproducible silica matrix forms the basis for the various Inertsil modifications and ensures reliable selectivities across the series. Appropriate Inertsil pre-column cartridges should be used to protect the analytical packing bed from particles and the sample matrix and to extend column lifespan.

Legal Notices

Inertsil is a registered trademark of the manufacturer GL Sciences Inc., Tokyo, Japan.