Inertsil C8 5µm column 4.6 x 250mm HPLC Column

The Inertsil C8 HPLC column 250x4.6mm, 5µm, is based on a classic octyl phase (also known as RP-8, C8) for reverse-phase chromatography. Compared to C18 phases, it offers lower hydrophobic interactions and can therefore provide faster elutions and altered selectivity. Inertsil C8 is particularly suitable for existing C8 methods and general RP-HPLC separations. Typical applications include pharmaceutical analysis, routine chemical analysis, hydrophobic active ingredients, method maintenance, and separations with reduced retention times.

Performance Characteristics and Benefits

• High-purity silica
• Controlled pore structure and reproducible surface
• High inertness due to reduced silanol and metal activity
• Excellent peak shapes for acidic, neutral, and basic analytes
• Reliable reproducibility for routine analysis

Additional Notes

The Inertsil series is based on a high-purity, spherical silica matrix whose pore structure, particle size distribution, and surface are carefully controlled during production. Low metal contamination and careful surface treatment reduce the activity of free silanol groups. This minimizes undesirable secondary interactions—particularly tailing and adsorption with basic or chelating analytes—and promotes stable retention times. This reproducible silica matrix forms the basis for the various Inertsil modifications and ensures reliable selectivities across the series. Appropriate Inertsil pre-column cartridges should be used to protect the analytical packing bed from particles and the sample matrix and to extend column lifespan.

Legal Notices

Inertsil is a registered trademark of the manufacturer GL Sciences Inc., Tokyo, Japan.