LiChroCART 125x4.0mm ChiraDex 100 Å β-cyclodextrin 5µm HPLC Cartridge Column

The ChiraDex HPLC column 125x4.0mm, 5µm, contains beta-cyclodextrin covalently bonded to spherical 100 Å silica particles. Enantiomers are separated by differently stable inclusion complexes in the hydrophobic cyclodextrin cavity as well as by stereoselective hydrogen bonding. ChiraDex exhibits broad enantioselectivity and is used, among other things, for chiral hydrocarbons, steroids, phenol esters, aromatic amines and five- to seven-membered heterocycles.

Features and Benefits

• Covalently bound beta-cyclodextrin selectors
• Broad enantioselectivity
• Chiral recognition via inclusion complexes and stereoselective hydrogen bonds
• Can be used with simple reverse-phase eluents in many cases
• High-resolution version available for higher separation performance

Additional Notes

ChiraDex utilizes the hydrophobic cavity and hydrophilic openings of beta-cyclodextrin to form diastereomeric inclusion complexes. Enantioselectivity depends on molecular size, substitution pattern, pH, organic content, and temperature. The silica-based material is typically operated within a pH range of approximately 3 to 7.5.

Legal Information

ChiraDex is a registered trademark of Merck KGaA, Darmstadt, Germany.