Kromasil 60-10-CN 20 x 250 mm

The Kromasil 60 CN HPLC column 250x20mm, 10µm, features a cyano modification on a 60 Å silica backbone. The cyano group provides dipole–dipole interactions and moderate polarity, allowing Kromasil 60 CN to be used in both normal-phase chromatography and reversed-phase chromatography. The phase offers a different selectivity compared with classical C18 phases and is particularly interesting for polar to mid-polarity compounds. Typical applications are diastereomer separations, pharmaceutical intermediates, natural products, pesticides, organic acids and method development with alternative selectivity.

Performance Characteristics and Benefits

• Spherical, fully porous silica with high mechanical stability
• High surface area and high pore volume for efficient separations and good loading capacity
• Narrow particle size distribution for high efficiency and reproducible results
• Broad phase spectrum for reverse-phase, normal-phase, HILIC, and SFC
• Suitable for analytical method development, routine analysis, scale-up, and preparative applications

Additional Information

The Kromasil series is based on highly stable, spherical, and fully porous silica particles. The silica matrix combines a high surface area, high pore volume, and a controlled pore structure with a narrow particle size distribution. This supports efficient packing beds, low pressure drops relative to performance, and good column and batch reproducibility. The Kromasil platform offers different pore sizes: 60 Å for small organic molecules, 100 Å for small molecules and peptides, and 300 Å for proteins and larger biomolecules. Appropriate Kromasil pre-column cartridges can be used to protect the analytical packing bed from particles, sample matrix, and hard-to-elute components.

Legal Notices

Kromasil is a registered trademark of the manufacturer Nouryon, Bohus, Sweden.