ACE 2 Extended Method Development UHPLC/HPLC Column Kit 50x4.6mm (SuperC18 C18-Amide AND CN-ES)

The Avantor ACE SuperC18 HPLC column 50x4.6mm, 2µm, is based on a proprietary encapsulated octadecylsilyl modification (other designations: ODS, RP-18, C18) for reversed-phase chromatography. The distinctive feature of the Avantor ACE SuperC18 is its high stability across an extended pH range, allowing flexible method development, pH screening and LC–MS-compatible mobile phases. The C18 selectivity combines hydrophobic retention with very good peak shape, particularly for basic or difficult-to-separate compounds. Typical applications include pharmaceutical method development, pesticide and herbicide analysis, vitamins, biomarker profiling and routine analyses with aqueous–organic eluents.

Performance Characteristics and Benefits

• Ultra-inert, high-purity, base-deactivated silica particles
• Broad range of selectivity for reverse-phase, normal-phase, and HILIC applications
• Fully porous 100 Å and 300 Å phases for small molecules and biomolecules
• Excellent peak shapes for acidic, basic, and neutral analytes
• High reproducibility from column to column and batch to batch

Additional Information

The Avantor ACE Series is based on high-purity, spherical silica with very low metal contamination and targeted base deactivation. Controlled surface chemistry reduces the activity of free silanol groups, which promotes symmetrical peaks and reproducible retention times, particularly for basic analytes. The portfolio includes classic fully porous 100 Å phases, alternative selectivities, and 300 Å wide-pore materials for larger molecules. Using compatible Avantor ACE guard cartridges protects the silica backbone of the analytical column from matrix components and can extend the column’s service life.

Legal Notices

Avantor ACE is a registered trademark of the manufacturer Avantor, Inc., Radnor, USA.