The Scherzo product range from Imtakt consists of three different mixed-mode HPLC columns for unique separations. The columns are well-suited for simultaneous analysis of polar and non-polar compounds. Both anionic and cationic compounds are retained on this columns. The following separation mechanisms can occur: Reversed-Phase, Anion‒ and Cation-Exchange.
Scherzo SS-C18: A large amount of strong ionic ligands loaded onto these ODS columns. They show improved retention of zwitterionic or weak ionic compounds.
 Scherzo SM-C18: Weak ionic ligands adequately loaded onto these ODS columns. They are designed for the separation of basic/acidic compounds at neutral pH conditions.
 Scherzo SW-C18: Only a low amount of strong ionic ligands loaded onto these ODS columns. They are effective for strong ionic compounds or basic compounds with formic acid containing eluents.
| Phase name | Modification  | Particle size  | Pore size  | End-capping  | C-content  | USP  | Surface area  | pH range  | Tmax  | 
| Scherzo SS-C18 | C18+SAX+SCX  | 3 µm  | 130 Å  | N/A  | N/A  | N/A  | N/A  | N/A  | N/A  | 
| Scherzo SM-C18 | C18+WAX+WCX  | 3 µm  | 130 Å  | N/A  | N/A  | N/A  | N/A  | N/A  | N/A  | 
| Scherzo SW-C18 | C18+SAX+SCX  | 3 µm  | 130 Å  | N/A  | N/A  | N/A  | N/A  | N/A  | N/A  | 
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