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ORpak CDBS-453, 4.6 x 150 mm, chiral HPLC column
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Product Description
The Shodex ORpak CDBS-453 chiral HPLC column 150x4.6mm, 3µm, is based on silica with a β-cyclodextrin derivative as the chiral selector. Enantiomers form differently stable inclusion complexes and additional hydrogen-bonding and dipole interactions, enabling the Shodex ORpak CDBS-453 to provide direct enantioselective separation. Typical applications are chiral pharmaceuticals and intermediates such as voriconazole, lamivudine or epinephrine; the phase corresponds to USP classification L45.
Features and Benefits
- Cyclodextrin-based chiral selectivity
- Direct enantiomer separation
- Silica-based, efficient packing material
- Multiple interaction mechanisms
Additional Notes
ORpak CDBS-453 uses a β-cyclodextrin derivative on porous silica. The chiral cavity of the cyclodextrin distinguishes enantiomers based on size, shape, and the spatial arrangement of functional groups. In addition, hydrogen bonding, dipole forces, and hydrophobic interactions can influence enantioselectivity. The mobile phase must be selected so that inclusion complex formation and additional interactions remain in balance.
Legal Information
ORpak is a registered trademark of the manufacturer Resonac Corporation, Tokyo, Japan.
Product Specification
| Flow Rate [ml/min] | 0.3 to 0.8 |
|---|---|
| Brand | ORpak |
| Product Type | HPLC Column |
| Length | 150 mm |
| Internal Diameter | 4.6 mm |
| Particle Size | 3 µm |
| Chemistry | Chiral |
| Chemistry Producers Term | CDBS |
| USP Class | L45 |
| Country of Origin | Japan |
| Column Type | Analytical Column |
| Solvent | (0.05 % CH3COOH + 0.2 M NaCl aq.)/CH3CN = 95/5 |
| Base Material | β-cyclodextrin |
| Hardware Material | Stainless Steel |
| Hardware Type | Ready-to-use Column |
| pH Minimum | 2.0 |
| pH Maximum | 7.0 |
| Temperature Minimum [°C] | 5 |
| Temperature Maximum [°C] | 60 |
| Mode of Separation | Chiral Chromatography |
| Technology | HPLC |
| Matrix | Silica |
| Number Theoretical Plates | ≥ 6,000 |
| Pressure Stability | 200 bar |
