Symmetry Shield RP 8 Intelligent Speed (IS) Column, 100Å, 5 µm, 3.9 mm X 20 mm, 1/pkg

The Waters SymmetryShield RP8 HPLC column 20x3.9mm, 5µm, is based on high-purity silica and features an embedded polar group in an octylsilyl phase (other designations: RP-8, C8). The Waters SymmetryShield RP8 was developed for separations in reversed-phase chromatography. The combination of the polar embedded group and C8 character reduces silanol interactions and shortens retention compared with RP18. The Waters SymmetryShield RP8 is used, among other things, for basic compounds, faster RP methods, methods at neutral pH and selectivity optimisation.

Performance Characteristics and Benefits

• High-purity, tightly specified silica
• Low residual silanol activity
• Reproducible peak shapes
• Shield phases with embedded polar groups
• 100 and 300 Å platforms

Additional Notes

Symmetry is based on high-purity silica and strictly controlled manufacturing and packing specifications. The classic C18 and C8 phases are designed to minimize unwanted silanol interactions and ensure reproducible peak shapes. In SymmetryShield, a polar group is embedded in the alkyl phase, which alters the selectivity and behavior of basic analytes compared to conventional alkyl phases. Symmetry300 uses a wide-pore 300 Å silica and extends the series to peptides, proteins, and other larger biomolecules.

Legal Information

Symmetry is a registered trademark of Waters Corporation, Milford, Massachusetts, USA.