XTerra MS C8 Column, 125Å, 2.5 µm, 4.6 mm X 50 mm, 1/pkg

The Waters XTerra MS C8 HPLC/UHPLC column 50x4.6mm, 2.5µm, is based on an octylsilyl phase (other designations: RP-8, C8) on HPT hybrid particles and is used primarily in reversed-phase chromatography. The MS-C8 chemistry combines LC-MS compatibility with reduced hydrophobic retention. Compared with C18 phases, the Waters XTerra MS C8 exhibits reduced hydrophobic retention, allowing very hydrophobic compounds to be eluted more quickly. Applications of the Waters XTerra MS C8 include fast LC-MS methods, very hydrophobic small molecules, screening analysis and method optimisation.

Performance Characteristics and Benefits

• Organic-inorganic hybrid particles
• Extended pH operating range
• MS and shield selectivities
• Good peak shapes for basic compounds
• Proven platform for established HPLC methods

Additional Information

XTerra is part of the first generation of Waters Hybrid Particle Technology. The organic-inorganic particle matrix is more resistant to alkaline hydrolysis than conventional silica and therefore allows for an expanded pH operating range. In addition to classic RP18 and RP8 phases, the series offers MS variants with low column bleed as well as Shield phases with embedded polar groups. XTerra is particularly relevant for existing methods where the original hybrid selectivity and historical method compatibility must be maintained.

Legal Information

XTerra is a registered trademark of Waters Corporation, Milford, Massachusetts, USA.