Nacalai Tesque / Cosmosil

Cosmosil

Cosmosil™ are HPLC columns from the Japanese manufacturer Nacalai Tesque of Kyoto. The phases are available with many, sometimes unique modifications. Base material is high-purity, spherical silica gel.

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Products

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Cosmosil® Protein-R Guard Cartridge 4.6mmx10mm

NT-21249-04

€213.00

Product Type: HPLC Guard Cartridges Length: 10 mm Internal Diameter: 4.6 mm Pore Size: 300 Å Chemistry: C18 (RP-18, ODS, Octadecyl) USP Class: L1 Manufacturer: Nacalai Tesque Delivery Time: approx. 8 days Endcapping: endcapped Bet Surface Area [m2/g]: 150.0 Mode of Separation: Reversed Phase Chromatography (RP) Hardware Type: Cartridges Matrix: Silica Particle Morphology: spherical, fully porous pH Minimum: 1.5 pH Maximum: 7.5 Technology: HPLC Temperature Minimum [°C]: 60

Cosmosil® 3C18-MS-Ⅱ Guard Cartridge 4.6mmx10mm

NT-21234-84

€235.00

Product Type: HPLC Guard Cartridges Length: 10 mm Internal Diameter: 4.6 mm Particle Size: 3 µm Pore Size: 120 Å Chemistry: C18 (RP-18, ODS, Octadecyl) USP Class: L1 Manufacturer: Nacalai Tesque Delivery Time: approx. 8 days Endcapping: endcapped Carbon Load: 16.0 % Bet Surface Area [m2/g]: 300.0 Mode of Separation: Reversed Phase Chromatography (RP) Hardware Type: Cartridges Matrix: Silica Particle Morphology: spherical, fully porous pH Minimum: 2.0 pH Maximum: 10.0 Technology: HPLC

Cosmosil® 3C18-AR-Ⅱ Guard Cartridge 4.6mmx10mm

NT-21231-14

€235.00

Product Type: HPLC Guard Cartridges Length: 10 mm Internal Diameter: 4.6 mm Particle Size: 3 µm Pore Size: 120 Å Chemistry: C18 (RP-18, ODS, Octadecyl) USP Class: L1 Manufacturer: Nacalai Tesque Delivery Time: approx. 8 days Endcapping: endcapped Carbon Load: 17.0 % Bet Surface Area [m2/g]: 300.0 Mode of Separation: Reversed Phase Chromatography (RP) Hardware Type: Cartridges Matrix: Silica Particle Morphology: spherical, fully porous pH Minimum: 1.5 pH Maximum: 7.5 Technology: HPLC

Cosmosil® 3πNAP Guard Cartridge 4.6mmx10mm

NT-21527-54

€208.00

Product Type: HPLC Guard Cartridges Length: 10 mm Internal Diameter: 4.6 mm Particle Size: 3 µm Pore Size: 120 Å Chemistry: Naphthylethyl Manufacturer: Nacalai Tesque Delivery Time: approx. 8 days Endcapping: endcapped Carbon Load: 11.0 % Bet Surface Area [m2/g]: 300.0 Mode of Separation: Reversed Phase Chromatography (RP) Hardware Type: Cartridges Matrix: Silica Particle Morphology: spherical, fully porous pH Minimum: 2.0 pH Maximum: 7.5 Technology: HPLC

Cosmosil® 3πNAP Packed Column 4.6mmx250mm

NT-21526-51

€559.00

Product Type: HPLC Column Length: 250 mm Internal Diameter: 4.6 mm Particle Size: 3 µm Pore Size: 120 Å Chemistry: Naphthylethyl Manufacturer: Nacalai Tesque Delivery Time: approx. 8 days Column Type: Analytical Column Endcapping: endcapped Carbon Load: 11.0 % Bet Surface Area [m2/g]: 300.0 Mode of Separation: Reversed Phase Chromatography (RP) Hardware Type: Ready-to-use Column Matrix: Silica Particle Morphology: spherical, fully porous pH Minimum: 2.0 pH Maximum: 7.5 Technology: HPLC

Cosmosil® 3πNAP Packed Column 4.6mmx150mm

NT-21525-61

€476.00

Product Type: HPLC Column Length: 150 mm Internal Diameter: 4.6 mm Particle Size: 3 µm Pore Size: 120 Å Chemistry: Naphthylethyl Manufacturer: Nacalai Tesque Delivery Time: approx. 8 days Column Type: Analytical Column Endcapping: endcapped Carbon Load: 11.0 % Bet Surface Area [m2/g]: 300.0 Mode of Separation: Reversed Phase Chromatography (RP) Hardware Type: Ready-to-use Column Matrix: Silica Particle Morphology: spherical, fully porous pH Minimum: 2.0 pH Maximum: 7.5 Technology: HPLC

Cosmosil® 3πNAP Packed Column 4.6mmx100mm

NT-21524-71

€476.00

Product Type: HPLC Column Length: 100 mm Internal Diameter: 4.6 mm Particle Size: 3 µm Pore Size: 120 Å Chemistry: Naphthylethyl Manufacturer: Nacalai Tesque Delivery Time: approx. 8 days Column Type: Analytical Column Endcapping: endcapped Carbon Load: 11.0 % Bet Surface Area [m2/g]: 300.0 Mode of Separation: Reversed Phase Chromatography (RP) Hardware Type: Ready-to-use Column Matrix: Silica Particle Morphology: spherical, fully porous pH Minimum: 2.0 pH Maximum: 7.5 Technology: HPLC

Cosmosil® 3πNAP Packed Column 4.6mmx75mm

NT-21523-81

€476.00

Product Type: HPLC Column Length: 75 mm Internal Diameter: 4.6 mm Particle Size: 3 µm Pore Size: 120 Å Chemistry: Naphthylethyl Manufacturer: Nacalai Tesque Delivery Time: approx. 8 days Column Type: Analytical Column Endcapping: endcapped Carbon Load: 11.0 % Bet Surface Area [m2/g]: 300.0 Mode of Separation: Reversed Phase Chromatography (RP) Hardware Type: Ready-to-use Column Matrix: Silica Particle Morphology: spherical, fully porous pH Minimum: 2.0 pH Maximum: 7.5 Technology: HPLC

Cosmosil® 3πNAP Packed Column 4.6mmx50mm

NT-21522-91

€476.00

Product Type: HPLC Column Length: 50 mm Internal Diameter: 4.6 mm Particle Size: 3 µm Pore Size: 120 Å Chemistry: Naphthylethyl Manufacturer: Nacalai Tesque Delivery Time: approx. 8 days Column Type: Analytical Column Endcapping: endcapped Carbon Load: 11.0 % Bet Surface Area [m2/g]: 300.0 Mode of Separation: Reversed Phase Chromatography (RP) Hardware Type: Ready-to-use Column Matrix: Silica Particle Morphology: spherical, fully porous pH Minimum: 2.0 pH Maximum: 7.5 Technology: HPLC

Cosmosil® 3πNAP Packed Column 3.0mmx250mm

NT-21521-01

€637.00

Product Type: HPLC Column Length: 250 mm Internal Diameter: 3.0 mm Particle Size: 3 µm Pore Size: 120 Å Chemistry: Naphthylethyl Manufacturer: Nacalai Tesque Delivery Time: approx. 8 days Column Type: Analytical Column Endcapping: endcapped Carbon Load: 11.0 % Bet Surface Area [m2/g]: 300.0 Mode of Separation: Reversed Phase Chromatography (RP) Hardware Type: Ready-to-use Column Matrix: Silica Particle Morphology: spherical, fully porous pH Minimum: 2.0 pH Maximum: 7.5 Technology: HPLC

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Technical Data

Phase-Name	Modification	Particle Size	Pore Size	End-capping	C-Content	USP	Surface	pH-Range	Tmax
Cosmosil C22-AR-II	Dococyl	5 µm	120 Å	+	19%	N/A	300 m²/g	2.0−7.5	N/A
Cosmosil 3C₁₈-EB	C₁₈	3 µm	120 Å	+	14.5%	L1	300 m²/g	2.0−10.0	N/A
Cosmosil C₁₈-MS-II	C₁₈	1.8, 3, 5, 15 µm	120 Å	+	16%	L1	300 m²/g	2.0−10.0	N/A
Cosmosil C₁₈-AR-II	C₁₈	3, 5, 15 µm	120 Å	+	17%	L1	300 m²/g	1.5−7.5	N/A
Cosmosil C₁₈-PAQ	C₁₈	5, 15 µm	120 Å	+	11%	L1	300 m²/g	2.0−7.5	N/A
Cosmosil 5C₁₈-AR-300	C₁₈	5 µm	300 Å	+	12%	L1	150 m²/g	1.5−7.5	N/A
Cosmosil Protein-R	C₁₈	5 µm	300 Å	+	N/A	L1	150 m²/g	1.5−7.5	N/A
Cosmosil C8-MS	Octyl	5 µm	120 Å	+	10%	L7	300 m²/g	2.0−7.5	N/A
Cosmosil 5C₈-AR-300	C₈	5 µm	300 Å	+	7%	L7	150 m²/g	1.5−7.5	N/A
Cosmosil C4-MS	Butyl	5 µm	120 Å	+	7%	L26	300 m²/g	2.0−7.5	N/A
Cosmosil 5C₄-AR-300	C₄	5 µm	300 Å	+	6%	L26	150 m²/g	1.5−7.5	N/A
Cosmosil TMS-MS	Trimetdyl	5 µm	120 Å	+	5%	L13	300 m²/g	2.0−7.5	N/A
Cosmosil PE-MS	Phenyletdyl	5 µm	120 Å	+	10%	L11	300 m²/g	2.0−7.5	N/A
Cosmosil 5Ph-AR-300	Phenyl	5 µm	300 Å	+	7%	L11	150 m²/g	1.5−7.5	N/A
Cosmosil CN-MS	Cyanopropyl	5 µm	120 Å	+	7%	L10	300 m²/g	2.0−7.5	N/A
Cosmosil PFP	Pentafluorophenyl	3, 5, 15 µm	120 Å	+	10%	L43	300 m²/g	2.0−7.5	N/A
Cosmosil SL-II	-	5 µm	120 Å	-	-	L3	300 m²/g	N/A	N/A
Cosmosil Cholester	Cholesteryl	5 µm	120 Å	+	20%	L101	300 m²/g	2.0−7.5	N/A
Cosmosil PBr	Pentabromobenzyl	5 µm	120 Å	+	8%	N/A	300 m²/g	2.0−7.5	N/A
Cosmosil nNAP	Naphtyletdyl	5 µm	120 Å	+	11%	N/A	300 m²/g	2.0−7.5	N/A
Cosmosil PYE	Pyrenyletdyl	5 µm	120 Å	+	18%	N/A	300 m²/g	2.0−7.5	N/A
Cosmosil NPE	Nitrophenyletdyl	5 µm	120 Å	+	9%	N/A	300 m²/g	2.0−7.5	N/A
Cosmosil HILIC	Triazole	5 µm	120 Å	-	N/A	L104	300 m²/g	N/A	N/A
Cosmosil 5HIC	Diol	5 µm	300 Å	N/A	7%	N/A	150 m²/g	1.5−7.5	N/A

Columns for saccharide analysis

Phase name	Modification	Particle size	Pore size	End-capping	C-content	USP	Surface area	pH range	Tmax
Cosmosil Sugar-D	Secondary/Tertiary Amine	5 µm	N/A	N/A	N/A	N/A	N/A	N/A	N/A
Cosmosil NH2-MS	Aminopropyl	5 µm	120 Å	+	4%	L8	300^m2/g	N/A	N/A

Columns for size exclusion chromatography (SEC, GFC)

Phase name	Modification	Particle size	Pore size	End-capping	C-content	USP	Surface area	pH range	Tmax
Cosmosil 5Diol-120-II	diol	5 µm	120 Å	N/A	N/A	N/A	N/A	N/A	N/A
Cosmosil 5Diol-300-II	Diol	5 µm	300 Å	N/A	N/A	N/A	N/A	N/A	N/A
Cosmosil 5Diol-1000-II	Diol	5 µm	1000 Å	N/A	N/A	N/A	N/A	N/A	N/A

Columns for ion exchange chromatography

Phase name	Modification	Particle size	Pore size	End-capping	C-content	USP	Surface area	pH range	Tmax
Cosmosil Type Q^[1]	^-CH3N+(_CH3₎₃	5 µm	1000 Å	N/A	N/A	N/A	N/A	N/A	N/A
Cosmosil Type Q-N^[1]	^-CH3N+(_CH3₎₃	5 µm	Non-Porous	N/A	N/A	N/A	N/A	N/A	N/A
Cosmosil Type S^[1]	-(_CH2₎^3SO3-	5 µm	1000 Å	N/A	N/A	N/A	N/A	N/A	N/A
Cosmosil Type S-N^[1]	-(_CH2₎^3SO3-	5 µm	Non-Porous	N/A	N/A	N/A	N/A	N/A	N/A
Cosmosil Type M^[1]	^-CH3N+(_CH3₎₃ + -(_CH2₎^3SO3-	5 µm	1000 Å	N/A	N/A	N/A	N/A	N/A	N/A
Cosmosil Type M-N^[1]	^-CH3N+(_CH3₎₃ + -(_CH2₎^3SO3-	5 µm	Non-Porous	N/A	N/A	N/A	N/A	N/A	N/A

[1] Base material: Hydrophilic polymer

Cosmosil RNA-SEC columns

product	Length	I.D.	Catalogue No.
Cosmosil RNA-SEC-1000	50 mm	7.5 mm	20785-91
Cosmosil RNA-SEC-1000	300 mm	7.5 mm	19380-21
Cosmosil RNA-SEC-2000	300 mm	7.5 mm	19381-11
CosmoCore 2.6C18	100 mm	7.5 mm	12614-71

Applications

Drugs (NSAIDs) COSMOSIL 1.8C18-MS-II 50x2.1mm

Strong hydrophobic properties of the phase allow the separation of challenging analytes

Comparison of the hydrophobicity of other columns with the Cosmosil 1.8C18-MS II from Nacalai Tesque

Peak Identities

1. Acetylsalicyclic acid 2. Loxoprofen 3. Ketoprofen 4. Naproxen 5. Phenylbutazone 6. Celecoxib 7. Diclofenac 8. Indometacin

Flavonoid analysis (COSMOSIL 1.8C18-MS-II 50x2.1mm)

Phase selectivity can enable difficult separations that co-elute on other columns

Comparison of the selectivity of other columns with the Cosmosil 1.8C18 MS-II from Nacalai Tesque

Peak Identities

1. Myricetin 2. 7,8-Dihydroxyflavone 3. Quercetin 4. Apigenin 5. Kaempferol 6. 7-Hydroxyflavone 7. 6-Hydroxyflavone 8. Flavone 9. Chrysin 10. 6-Methoxyflavone 11. 3-Hydroxyflavone 12. 5-Hydroxyflavone

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Applications

Technical Support

HPLC
Nacalai Tesque Cosmosil - Cosmocore Technical Notes

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