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Inertsil Hybrid
Inertsil Hybrid HPLC columns are silica-based chromatography columns featuring a hybrid organic-inorganic bonding technology developed by the manufacturer GL Sciences, Japan. The special hybrid silica material ensures exceptional stability of the HPLC columns across a wide pH range of 1.0–12.0 for modified Inertsil Hybrid phases and 1.0–10.0 for the unmodified phase. High pH values are particularly suitable for the analysis of bases, as these can be analysed with more symmetrical peaks when in a neutral state.
Advantages at a glance:
- pH range 1-12 for acidic and alkaline conditions
- Excellent reproducibility from batch to batch
- Compatible with LC/MS, LC/MS/MS and high pressure LC systems
- High durability and long lifetime, even at basic pH
- Compatible with 100% aqueous mobile phases
- Hardware: Stainless steel (SS) and biocompatible PEEK
Applications: Guanine-based antiviral analytes (acyclovir), nucleoside-based antiviral drugs (ribavirin), macrolide antibiotics (azithromycin), antihistamines (azelastine, loratadine), antidepressants (sertraline, amitriptyline)
- Inertsil
- Inertsil Hybrid
- InertSustain
- InertSustain Swift
- InertCap
- InertSep
- Titansphere
- LD249 Gas Leak Detector
- GF-1010 Digital Gas Flow Meter
- Bioptic
- GL Sciences-HayeSep
- GL Sciences-Porapak
- GL Sciences-TC
- GL Sciences-Tenax
- GL Sciences-Unibeads
- InertCore
- InertSep WAX FF/GCB
- InertSphere
- MonoCap
- MonoFas
- MonoSpin
- MonoTrap
- OPTIC
- ProteoSil
- SYPRON
Technical Data
| Phase | Modification | Particle size | Pore size | Surface area | Carbon content | End-capped | USP | pH range | Temperature |
| Inertsil Hybrid-C18 | Hybrid C18 | 1.7, 3.5, 5 µm | 165 Å | 185 m²/g | 15 %C | + | L1 | 1.0–12.0 | 80°C (pH 1.0–10.0) 60°C (pH 11.0–12.0) |
| Inertsil Hybrid-Si | Hybrid Si | 1.7, 3.5, 5 µm | 165 Å | 185 m²/g | N/A | - | L3 | 1.0–10.0 | N/A |
| Phase | Max Pressure |
| Inertsil Hybrid-C18 | 1.7 μm: 18,000 psi (124 MPa) - PEEK hardware: 14,500 psi (100 MPa) 3.5 μm: 7,200 psi (50 MPa) 5 μm: 6,000 psi (40 MPa) |
What characterises the Inertsil Hybrid-C18?
- high pH stability
- higher stability compared to other hybrid or pH-stable phases
- High lot-to-lot reproducibility for all particle sizes
When will you benefit from the Inertsil Hybrid C18?
Change in selectivity due to the pH value
Peak identities
1. epinastine 2. cetirizine 3. fexofenadine 4. chlorpheniramine 5. ketotifen 6. hydroxyzine 7. triprolidine 8. azelastine 9. loratadine 10. homochlorocyclizine 11. clemastine
Applications
Separation of antihistamines
Peak identities
1. epinastine 2. chlorpheniramine 3. fexofenadine 4. triprolidine 5. ketotifen 6. cetirizine 7. azelastine 8. hydroxyzine 9. homochlorocyclizine 10. clemastine 11. loratadine
Test conditions
Column: Inertsil Hybrid-C18 150x2.1 mm, 3.5 µm
Analysis of antidepressants
Peak identities
1. nortriptyline 2. imipramine 3. amitriptyline 4. sertraline 5. clomipramine 6. mianseline
Test conditions
Column: Inertsil Hybrid-C18 150x2.1 mm, 3.5 µm
Downloads
Brochures
GL Sciences Inertsil Hybrid C18 Brochure
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