Chiralcel OZ-H 5µm 50x4.6mm HPLC Guard Columns

The Chiralcel OZ-H Front pillars 50x4.6mm, 5µm, are used to protect chiral cells OZ-H HPLC and SFC columns are used. They retain particles, matrix components and strongly adsorbing substances before they reach the Chiralcel column. This helps to stabilise peak shape, resolution and column life in chiral separation methods. As these are packed pre-columns, no mounting bracket is required.

Features and Benefits

• Cellulose-based chiral polysaccharide phases with established enantioselectivity
• Coated Chiralcel phases on spherical silica with proven selectivity
• Wide range of applications in normal-phase HPLC, SFC, and available RP variants
• Complementary modifications for screening, method optimization, and preparative separations

Additional Notes

The Chiralcel phases are based on cellulose-derived polysaccharides that are physically coated onto a silica scaffold to serve as chiral selectors. The cellulose structure creates an ordered, chiral environment, while the specific derivatization—for example, phenylcarbamate, benzoate, acetate, or cinnamate—determines the specific hydrogen-bond, dipole, π-π, and hydrophobic interactions. The advantage of the coated Chiralcel phases lies in their very broad, proven selectivity and often good loading capacity, particularly for preparative separations. The disadvantage is limited solvent compatibility: highly solvent organic solvents can impair the physically applied polysaccharide layer. For a robust method, Chiralcel pre-column cartridges with a suitable phase should be used, as chiral polysaccharide phases can be sensitive to matrix components, particles, and strongly adsorbing sample components.

Legal Notices

Chiralcel is a registered trademark of the manufacturer Daicel Corporation, Osaka, Japan.