Chiralcel OD 10µm 250x20mm SFC Column

The Chiralcel OD HPLC column 250x20mm, 10µm, based on cellulose as the polysaccharide backbone. The specific modification used is cellulose tris(3,5-dimethylphenylcarbamate); the chiral stationary phase is physically coated and applied to spherical silica. Chiralcel OD is primarily used in normal-phase chromatography, SFC and the corresponding reverse-phase variants. In this process, the phase separates enantiomers via hydrogen bonding, dipole–dipole interactions, π–π interactions and steric fit. Typical applications of the Chiralcel OD include active pharmaceutical ingredients, chiral fine chemicals, synthetic intermediates and screening tasks involving a broad range of substances. The dimethyl-substituted phenylcarbamate structure makes Chiralcel OD a widely used reference phase for cellulose-based chiral methods.

Features and Benefits

• Cellulose-based chiral polysaccharide phases with established enantioselectivity
• Coated Chiralcel phases on spherical silica with proven selectivity
• Wide range of applications in normal-phase HPLC, SFC, and available RP variants
• Complementary modifications for screening, method optimization, and preparative separations

Additional Notes

The Chiralcel phases are based on cellulose-derived polysaccharides that are physically coated onto a silica scaffold to serve as chiral selectors. The cellulose structure creates an ordered, chiral environment, while the specific derivatization—for example, phenylcarbamate, benzoate, acetate, or cinnamate—determines the specific hydrogen-bond, dipole, π-π, and hydrophobic interactions. The advantage of the coated Chiralcel phases lies in their very broad, proven selectivity and often good loading capacity, particularly for preparative separations. The disadvantage is limited solvent compatibility: highly solvent organic solvents can impair the physically applied polysaccharide layer. For a robust method, Chiralcel pre-column cartridges with a suitable phase should be used, as chiral polysaccharide phases can be sensitive to matrix components, particles, and strongly adsorbing sample components.

Legal Notices

Chiralcel is a registered trademark of the manufacturer Daicel Corporation, Osaka, Japan.